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OxyELITE Pro

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Rp 475,000

The OxyELITE Pro™ lineup.

Rauwolfia Canescens (Rauwolscine)

This particular compound has been suggested to block off & deactivate the Alpha-2 receptor!*

It's related to yohimbine, a compound which is often included in various thermogenic formulas because of its ability to antagonize alpha 2-adrenoceptors, allowing lipolysis itself, while also allowing lipolysis to continue from beta adrenoceptoragonism as well (11,12).*

Here's the problem:  While antagonizing alpha 2-adrenoceptors is great, yohimbine unfortunately also does the same for alpha 1-adrenoceptors - and this may actually hinder lipolysis (13).*

So, on the other hand, while yohimbine may help improve lipolysis by antagonizing alpha 2-adrenoceptors, it may also prevent lipolysis from occurring by antagonizing alpha 1-adrenoceptors...*

Kind of defeats the purpose, huh? It's like robbing Peter to Pay Paul.

The end result may be only a mediocre or small effect upon fat loss, or no detectable fat loss at all, which is what has been suggested in some of the literature with yohimbine supplementation (14-17). *

Rauwolscine on the other hand, may be just as effective at antagonizing alpha 2-adrenoceptors as yohimbine, yet less potent at alpha 1-adrenoceptors (18), which may make it less likely to reduce lipolysis by inhibiting alpha 1-adrenoceptor activity when compared to yohimbine.*

Bauhinia purpurea L (Leaf & Pod [standardized for Bauhiniastatins 1-4])

This particular extract is very exciting because, due to various factors (e.g., stress, dieting, overtraining), many individuals may have impaired conversion of T4 to T3.*

We all know the thyroid plays an important role in metabolic rate.

An extract from the plant Bauhinia purpurea has been suggested in healthy adult animal models to increase T4 while also increasing T3 by an amazing 83%!* (21)

Yet another reason that increasing thyroid hormone is so important is because it's been surmised to sensitize or increase the lipolytic effects of adrenergic stimulation in fat cells* (33).

Due to the results of the studies, the authors concluded that the plant is likely increasing the conversion of peripheral T4 to T3.

Bacopa monnieri (Leaf)

This plant has also been suggested in an animal model to naturally promote thyroid hormone production.* In this case, the plant extract was suggested to increase T4 levels when compared to controls* (23).

In this case, however, since there was no increase in T3 seen, the authors concluded that the plant extract can directly stimulate the release of T4 from the thyroid gland, as opposed to Bauhinia purpurea, which increased the conversion of T4 to T3.

Geranium [Stems](extracted for 1,3-Dimethylamylamine)

Geranium has been used for centuries as a food additive and part of certain cultures' regular diets.

Cirsium Oligophyllum (Whole Plant Extract)

Our use of this plant is based upon an animal study which had suggested that compared to a control group, the extract studied was able to reduce the gain of bodyweight and fat mass and specifically seemed to target subcutaneous fat mass in rats over that of visceral fat mass!* (5)

Pharmacological studies suggest that the active constituent possesses beta adrenoceptor agonist activity and may stimulate lipolysis in subcutaneous fat cells.*

Yet another similarity that the Cirsiumoligophyllum extract shares with beta adrenoceptor agonists is that it can work synergistically with caffeine, potentially producing a more powerful lipolytic effect (5).*

In fact, the potency of caffeine & Cirsium Oligophyllum combined was nearly 10 times greater than Cirsium Oligophyllum by itself in this study.

Caffeine

Caffeine is often noted for its ability to increase resting energy expenditure, while also increasing lipolysis and lipid oxidation (6-8)...*

In addition, it is noted for its ability to increase feelings of energy, alertness, concentration and euphoric effects (9,10).*

Everyone throws caffeine in their formula...but few know why...we have a specific purpose on why we included it...

...Aside from the benefits that caffeine alone imparts, it may also provide synergistic effects when combined with other ingredients in OxyELITE Pro™...*

...In fact, in the study performed with Cirsiumoligophyllum, they surmised exactly that!*

Caffeine was suggested to provide an increase in the effectiveness of the extract at promoting lipolysis in subcutaneous fat cells (5)...*

How OxyELITE Pro™ Attacks BAT (Brown Adipose Tissue)

First, Geranium extract has sympathomimetic properties & this makes it a candidate for increasing UCP-1 expression and recruiting or regaining BAT so that we may use it once again.*

Secondly, Cirsium oligophyllum has beta adrenoceptor agonist activity and, as would be expected, has actually been suggested to increase UCP-1 activity in BAT of an animal model (5).*

Third, caffeine has been suggested to increase norepinephrine.

This increased norepinephrine again contributes to increasing UCP-1 activity in BAT, unfortunately, it also ends up activating alpha 2-adrenoceptors...

...And by doing this, it actually inhibits some of the potential lipolytic and thermogenic activity of norepinephrine by inhibiting adenylyl cyclase (i.e., the enzyme which allows for cyclic adenosine monophosphate or cAMP formation and what ultimately leads to lipolysis) activity (25,28).*

This is where rauwolscine comes in to play as it is an alpha 2-adrenoceptor antagonist. It prevents this inhibition of adenylyl cyclase and thus may potentially lead to a further increase in cAMP, lipolysis and thermogenesis via UCP-1...*

Again, this is where rauwolscine differs from yohimbine...

You see, the alpha 1-adrenoceptor is also activated by norepinephrine and it also contributes to increased UCP-1 activity and subsequent thermogenesis (28,29,31,32).*

At least one partial mechanism for how the alpha 1-adrenoceptor exerts such an effect is by supporting the conversion of T4 to T3 within BAT, which in turn increases UCP-1 expression.*

...So, although yohimbine has some beneficial effect upon fat loss, it's this blocking of activity at the alpha 1-adrenoceptor that becomes its downfall. Rauwolscine is less potent at antagonizing the alpha 1-adrenoceptor and thus makes a much better agent to use for fat loss.*

Last, but certainly not least, we still have both of our plant extracts designed to increase the release of T4 (Bacopa monnieri) and support the conversion of T4 to T3 (Bauhinia purpurea).*

As we just mentioned, T3 plays a role in UCP-1 expression so if we can elevate levels further, it is beneficial for a number of reasons...

...Of course, the fact that T3 can up-regulate beta adrenoceptor expression while down-regulating alpha 2-adrenoceptor expression, all while inhibiting phosphodiesterase (i.e., an enzyme that breaks down cAMP) activity further adds to increase or potentiate the effectiveness of the other ingredients (33).*

What's in USPlabs OxyELITE Pro?

90 Capsules Supplement Facts Serving Size1Capsule Servings Per Container90 Amount Per Serving % Daily Value Proprietary Blend 119.5mg * Bauhinia Purpurea L. (Leaf And Pod)(Standardized For Bauhnia-Statins 1-4), Bacopa Monniera (Leaf), 1,3-Dimethylamylamine (Geranium [Stem]), Cirsium Oligophyllum (Whole Plant Extract), Rauwolscine (Rauvolfia Canescens L. [Leaf And Root]) Caffeine 100mg * * Percent Daily Values are based on a 2,000 calorie diet † Daily Value not established

Other Ingredients: Modified Food Starch, Gelatin, Vegetable Stearate, Silicon Dioxide, Red #3, Blue #1, Red #40, Titanium Dioxide

Directions For USPlabs OxyELITE Pro: As a dietary supplement, take 1-2 capsules on an empty stomach before breakfast. Take an additional 1 capsule six to eight hours later on an emptystomach, if needed. Due to extreme potency, begin by taking 1 capsule before breakfast and 1 capsule six to eight hours later to assess tolerance. DO NO USE PRODUCT FOR LONGER THAN 8 WEEKS FOLLOWED BY A SUBSEQUENT 4 WEEK BREAK. DO NOT EXCEED 3 CAPSULES IN ANY 24 HOUR PERIOD.